Scientific Programme
Scientific
Programme
| 02 NOVEMBER 2022 – WEDNESDAY | |
| 12.00 | Registration |
| HALL – A (This session will be in Turkish) | |
| 13.30-16.30 | Biyoteknolojik İlaçlarda Klinik Çalışmalar-Güvenlik Değerlendirmeleri Safety Evaluations and Clinical Studies in Biotechnological Products |
| Biyoteknolojik İlaçlar ve Üretim Süreçleri Devrim Demir Dora |
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| Biyobenzer İlaçlarda Klinik Çalışmalar ve Karşılaştırılabilirlik İrfan Çiçin |
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| Biyobenzer Ürünlerde Ekstrapolasyon, Değiştirilebilirlik M.Cem Ar |
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| Biyoüstünler Alper B. İskit |
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| Biyolojik ve Biyobenzer İlaçlarda Farmakovijilans, İzlenebilirlik ve Risk Yönetimi Semra Şardaş |
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| 17.00-18.30 | Opening Ceremony |
| 17.30-18.15 | Opening Lecture The history of the advancement of toxicology in Turkey Ali Esat Karakaya |
| 18.00-20.00 | Opening Reception |
| 20.00 | Dinner |
| 03 NOVEMBER 2022 – THURSDAY | |
| HALL – A | |
| 9.00-9.45 | Plenary Lecture Safety evaluation of pharmaceuticals and medical products Mary Ellen Cosenza |
| 9.45-10.15 | Coffee Break |
| HALL – A, SESSION 1 | |
| 10.15-12.15 | Genotoxic Impurities in Pharmaceutical Compounds |
| 10.15-10.45 | Several years of experience with the use of the staged TTC concept (less than lifetime) for genotoxic impurities in drugs Lutz Mueller |
| 10.45-11.15 | Strategies on the assessment of genotoxic impurities in pharmaceuticals Andreas Czich |
| 11.15-11.45 | Regulation of Genotoxic Impurities – Guidelines and Experiences since 2006 Roland Froetschl |
| 11.45-12.15 | Genotoxic impurities and other possible impurities in pharmaceutical products: From the application perspective Ahmet Aydın |
| 12.15-13.30 | Lunch |
| HALL – A | |
| 13.30-14.15 | Plenary Lecture Environmental pollutants and severity of COVID-19 and other infections by respiratory virus Jose L. Domingo |
| 14.15-14.30 | Coffee Break |
| HALL – A, SESSION 2 | |
| 14.30-16.45 | Vaccine Safety-Toxicity and Clinical Trials |
| Vaccine Safety and Toxicity. What have We Learned from COVID-19 Pandemic Pınar Erkekoğlu |
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| Clinical Trials of COVID-19 Vaccines Serhat Ünal |
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| Vaccine Hesitancy Levent Akın |
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| Pharmacoeconomic Aspects of COVID-19 Vaccines Zafer Çalışkan |
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| Characterization and Quality Control Procedures for Vaccines: A Special Focus on COVID-19 Vaccines Emirhan Nemutlu |
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| HALL – B, SESSION 3 | |
| 14.30-16.45 | Scientific Approach to Chemical Warfare and Fourth Generation Nerve Agents_ Novichoks |
| A generic presentation on fourth generation agents and their risks – novel therapeutic options for nerve agents/organophosphates poisoning Valentine Nzenzung |
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| Case studies for Novichok incidents in UK Paul Russell |
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| Navalyn incident and verification of nerve agent exposure including Novichok in human samples Sermet Sezigen |
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| Review-based evaluation of decontamination techniques after Novichok exposure Denis Josse |
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| Chemical countermeasures: Future developments Laura Cochrane |
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| 16.45-17.00 | Coffee Break |
| HALL – A, SESSION 4 | |
| 17.00-19.00 | Current approaches on detecting the DNA damage and repair of chemicals |
| Mode of action (MOA) based threshold for genotoxic carcinogens: Benzene case Neslihan Aygün Kocabaş |
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| Mitochondrial DNA damage as genotoxicity marker Nadja Cristhina de Souza Pinto |
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| Oligonucleotide Characterization for Emerging Modalities Erdem Çoşkun |
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| The impacts of prominent detoxifying and repair gene polymorphisms on neurological diseases Bensu Karahalil |
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| Genetic risks from heat-damaged DNA in food Miral Dizdaroğlu |
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| HALL – B, SESSION 5 | |
| 17.00-19.00 | Environmental Biomonitoring of Hazardous Substances |
| Air pollution context and biomonitoring in Sarajevo, Bosnia and Herzegovina Anja Haveric |
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| Does Occupational Toxicology of Metals have any Future in Developed Countries? Petar Bulat |
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| Monitoring air pollution and the health-related biomarkers: lessons from HUMNap Marco Geric |
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| Tobacco biomonitoring (cotinine) in pregnant women and perinatal outcomes Carla Costa |
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| ….TBA….. Mykola Prodanchuk |
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| 20.00 | Dinner |
| 04 NOVEMBER 2022 – FRIDAY | |
| HALL – A | |
| 9.00-9.45 | Plenary Lecture Safety Evaluation of Food Additives Yalçın Duydu |
| 9.45-10.15 | Coffee Break |
| HALL – A, SESSION 6 | |
| 10.15-12.15 | The Safety of Nanomaterials |
| Possible risks of interactions between nanometal mixtures and chemical contaminant in aquatic environment Murat Özmen |
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| Effect of BaSO4 nanoparticles on human lung cells under different culture conditions Heidi Foth |
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| Effects of Carbon Nanomaterials on environment Bertrand Pourrut |
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| Genotoxicity of engineered nanomaterials: New approaches to hazard and risk assessment Maria Dusinska |
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| 12.15-13.30 | Lunch |
| HALL – A, SESSION 7 | |
| 13.30-15.30 | In Silico Toxicology |
| Regulatory Applications of Computational Toxicology: Progress and Strategies to Ensure Wider Use Kristie Sullivan |
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| In silico approaches to assess the potential environmental effects of diverse chemicals Melek Türker Saçan |
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| Filling data gap for toxicological evaluation of pharmaceuticals: In Silico approach Muhammed Hamitoğlu |
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| In silico toxicological evaluation of drug impurities aligned with ICH M7. A case study for methylprednisolone aceponate impurities Gülçin Tuğcu |
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| HALL – B, SESSION 8 | |
| 13.30-15.45 | Application of Comet Assay in Human Biomonitoring |
| The comet assay in human biomonitoring: results from the COST Action hCOMET Andrew Collins |
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| Standardization of comet assay in salivary leucocytes for human biomonitoring studies Blanca Laffon |
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| Exposure to trihalomethanes in indoor swimming pools and DNA damage Joao Paolo Texeira |
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| Effect of a meat-based diet on fecal water genotoxicity: a randomized clinical trial in healthy subjects Lisa Giovannelli |
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| Different DNA damage levels assessed by the alkaline comet assay in Swiss albino mice after combine exposure to radiotherapeutic doses of ionizing radiation and different volatile anaesthetics Mirta Milic |
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| 15.45-16.00 | Coffee Break |
| HALL – A, SESSION 9 | |
| 16.00-18.00 | Organ-specific Toxic Pathways: recent progress in drug-induced adversities |
| Progress on mechanism of paracetamol-induced kidney damage Hilmi Orhan |
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| Adverse outcome pathways for in vitro prediction of liver toxicity Mathieu Vinken |
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| The role of mitochondria in cell death and regeneration during acetaminophen hepatotoxicity Hartmut Jaeschke |
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| Increasing complexity of in vitro models for drug-induced nephrotoxicity enhances their predictive value Roos Masereeuw |
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| HALL – B, SESSION 10 | |
| 16.00-18.00 | Lipids in Health and Diseases |
| Mass Spectrometry Imaging of Cholesterol Metabolism in Brain William Griffiths |
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| Sterol markers of cholesterol and bile acid metabolism Dieter Luetjohann |
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| Attenuation of oxysterols-induced cytotoxicity by Lorenzo’s oil, a 4:1 mixture of oleic and erucic acid: potential benefits in age-related disease Gerard Lizard |
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| Sphingolipid metabolism in toxicological exposures Suna Sabuncuoglu |
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| 19.30 – | Gala Dinner |
| 05 NOVEMBER 2022 – SATURDAY | |
| HALL – A | |
| 9.00-9.45 | Plenary Lecture Mutidrug Resistance Protein-4 (Mrp4): A New Member in the Constellation of Factors Contributing to Non-alcoholic Liver Disease and Metabolic Syndrome José E. Manautou |
| 9.45-10.15 | Coffee Break |
| HALL – A, SESSION 11 | |
| 10.15-12.15 | Current Concerns about Endocrine Disrupting Chemicals |
| Causality Between Prenatal Exposure to Pharmaceuticals and Childhood Obesity Hande Gürer Orhan |
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| Epigenetic Effects of Endocrine Disrupting Chemicals Belma Koçer Gümüşel |
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| Zebrafish as a Model for Chemical Induced Adipogenesis and Related Metabolic Diseases Jorke Kamstra |
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| Risk Assessment of Endocrine Disruptors Johanna Zilliacus |
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| HALL – B, SESSION 12 | |
| 10.15-12.15 | Conceptual Models in Immunotoxicology: alternative approaches and computational strategies |
| Key characteristics of immunotoxicants: the way forward? Dori E. Germolec |
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| In vitro tests addressing immunotoxicity with a focus on immunosuppression Emanuela Corsini |
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| Integrated testing strategy for immunotoxicity Marco Corvaro |
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| The Universal Immune System Simulator: an in silico model to predict the risk associated with exposure to immunotoxicants Francesco Pappalardo |
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| 12.15 | Closing Remarks |
