Scientific Programme


HALL – A (This session will be in Turkish)
13.30-16.00Biyoteknolojik İlaçlarda Klinik Çalışmalar-Güvenlik Değerlendirmeleri
Safety Evaluations and Clinical Studies in Biotechnological Products
Chairs: Semra Şardaş, Gül Özhan
13.30-14.00Biyoteknolojik İlaçlar ve Üretim Süreçleri
Devrim Demir Dora
14.00-14.30Biyobenzer İlaçlarda Klinik Çalışmalar ve Karşılaştırılabilirlik
İrfan Çiçin (Online)
14.30-15.00Biyobenzer Ürünlerde Ekstrapolasyon, Değiştirilebilirlik
M.Cem Ar (Online)
Alper B. İskit
15.30-16.00Biyolojik ve Biyobenzer İlaçlarda Farmakovijilans, İzlenebilirlik ve Risk Yönetimi
Semra Şardaş
17.00-18.30Opening Ceremony
17.30-18.15Opening Lecture
Chair: Nurşen Başaran
The History of the Advancement of Toxicology in Turkey
Ali Esat Karakaya
18.00-20.00Opening Reception
09.00-9.45Plenary Lecture
Chair: Ali Esat Karakaya
Non-Pharmacological Mechanism in Substance-Based Medical Devices/Challenges in Regulatory Definition
Marco Racchi
09.45-10.00Coffee Break
10.00-12.00Genotoxic Impurities in Pharmaceutical Compounds
Chairs: Lutz Mueller, Ahmet Aydın
10.00-10.30The staged TTC concept in the evaluation og genotoxic impurities in drugs
Lutz Mueller
10.30-11.00Strategies on the assessment of genotoxic impurities in pharmaceuticals
Andreas Czich (online)
11.00-11.30Regulation of Genotoxic Impurities – Guidelines and Experiences since 2006
Roland Froetschl
11.30-12.00Genotoxic impurities and other possible impurities in pharmaceutical products: From the application perspective
Ahmet Aydın
13.30-14.15Plenary Lecture
Chair: José E. Manautou
Chemical Stewardship through Sustainability Lenses
Salmaan H Inayat-Hussain
14.30-17.00Vaccine Safety-Toxicity and Clinical Trials
Chairs: Asuman Karakaya, Pınar Erkekoğlu
14.30-15.00Vaccine Safety and Toxicity. What have We Learned from COVID-19 Pandemic
Pınar Erkekoğlu
15.00-15.30Clinical Trials of COVID-19 Vaccines
Serhat Ünal
15.30-16.00Vaccine Hesitancy
Levent Akın
16.00-16.30Pharmacoeconomic Aspects of COVID-19 Vaccines
Zafer Çalışkan
16.30-17.00Characterization and Quality Control Procedures for Vaccines: A Special Focus on COVID-19 Vaccines
Emirhan Nemutlu
17.00-17.15Coffee Break
14.30-17.00Current approaches on detecting the DNA damage and repair of chemicals
Chairs: Bensu Karahalil, Neslihan Aygün Kocabaş
14.30-15.00Genetic risks from heat-damaged DNA in food
Miral Dizdaroğlu (online)
15.00-15.30Mode of action (MOA) based threshold for genotoxic carcinogens: Benzene case
Neslihan Aygün Kocabaş
15.30-16.00Mitochondrial DNA damage as genotoxicity marker
Nadja Cristhina de Souza Pinto (online)
16.00-16.30The impacts of prominent detoxifying and repair gene polymorphisms on neurological diseases
Bensu Karahalil
16.30-17.00In vitro genotoxicity of two graphene oxides before and after prolonged mild thermal treatment
Sanin Haveric
17.00-17.15Coffee Break
17.15-19.15Scientific Approach to Chemical Warfare and Fourth Generation Nerve Agents_Novichoks
Chairs: Onur Erdem, Sermet Sezigen
17.15-17.45A generic presentation on fourth generation agents and their risks – novel therapeutic options for nerve agents/organophosphates poisoning
Ahmet Aydın
17.45-18.15Case studies for Novichok incidents in UK and Russia
Sermet Sezigen
18.15-18.45Review-based evaluation of decontamination techniques after Novichok exposure
Denis Josse (online)
18.45-19.15In-vitro and Pre-Clinical Studies of Decontamination Efficacy of Chemical Warfare agents from the skin
Laura Cochrane (online)
17.15-19.15Environmental Biomonitoring of Hazardous Substances
Chairs: Anja Haveric, Yalçın Duydu
17.15-17.45Air pollution context and biomonitoring in Sarajevo, Bosnia and Herzegovina
Anja Haveric
17.45-18.15Does research in the field of Occupational Toxicology of Metals have any Future in Developed Countries?
Petar Bulat
18.15-18.45Tobacco during pregnancy: looking at self-reported tobacco exposure, urinary cotinine levels and perinatal outcomes
Carla Costa
18.45-19.15Monitoring air pollution and the health-related biomarkers: lessons from HUMNap
Katarina Matkovic
14.30-16.30 Industry Sponsored Workshop / MAT-TEK
The workshop will provide a brief overview of in vitro 3D reconstructed human tissue models and their use in toxicology and pharmacology as well as the practical demonstration of EpiDerm Skin Irritation Test (SIT) according to OECD test guideline 439 (TG 439).
EpiDerm 3D human tissue model is used across a diverse range of applications including safety and risk assessment, and biological efficacy. Simple protocols and the evaluation of early cellular endpoints allow researchers to acquire data in few days. EpiDerm, a Reconstructed Human Epidermis (RHE), is ready-to-use, highly differentiated 3D tissue model consisting of normal, human-derived epidermal keratinocytes (NHEK) cultured on specially prepared tissue culture inserts cultured at the air-liquid interface (ALI) and allows for the evaluation of topically applied compounds, chemicals, cosmetic/personal care product ingredients and final formulations. With multiple ECVAM validations and OECD accepted test guidelines, EpiDerm is a proven in vitro model system for chemical, pharmaceutical and skin care product testing. EpiDerm SIT is validated and accepted method under OECD TG 439, EpiDerm Skin Corrosion test as OECD TG 431 and EpiDerm phototoxicity test as OECD TG 498.
Participants will have a hands-on opportunity to practice the EpiDerm SIT with actual tissue models. The workshop is suitable for everybody who would like to practice the method, consult the specific problem, get information as well as those who are just considering the use of in vitro models in their research.
Please, sign in at MatTek´ s booth. Number of participants for practical work is limited to 30.
16.30-16.45Coffee Break
16.45-18.50Industry Sponsored Presentation & Oral Presentations 1
Chairs: Ülkü Ündeğer Bucurgat, Bülent Ergun
16.45-17.00 Industry Sponsored Presentation / Redoks
Orbitrap (HR)-MS Applications in Toxicological Drug Screening
17.00-17.10Comparison of EU and TR safety guidelines on the use of nanomaterials in cosmetics
Yağmur Emre Arıcan
17.10-17.20In silico prediction of ADME and toxicity profiles of the drug candidates
Tuğçe Yeşil
17.20-17.30Evaluation of neopterin levels and kynurenine pathway in acute coronary syndrome patients
Sonia Sanajou
17.30-17.40Modifying Effects of Gender on the Toxicity of Methyl Mercury and Thimerosal
Selinay Başak Erdemli-Köse
17.40-17.50Evaluation of Possible Toxic Effects of Preservatives and Adjuvants Used in Vaccines
Anıl Yirun
17.50-18.00Comparison of possible cytotoxic effects in healthy and cancer cells and evaluation of antioxidant capacities of polymeric nanoparticles encapsulated with naringin and berberine
Jülide Secerli
18.00-18.10Hepatotoxicity induced by low doses of Pb: subacute toxicity study in rats and Benchmark modeling
Dragana Javorac
18.10-18.20The protective role of UMCA on bleomycin-induced lung fibrosis in rats
Sezgin Aydemir
18.20-18.30Are rare earth elements safe for use in zootechny?; trophic transfer and effects of lanthanide nanoparticles in a simple food web
Daniel Mark Lyons
18.30-18.40Microplastics: How aware are we?
Özge Sultan Zengin

Medroxyprogesterone Acetate And Ethodolac Exposure Durıng Pregnancy
Elif Onat

Cerebral oxidative stress and histological changes induced by di (2-ethyl hexyl) phthalate exposure in early adolescent and adolescent periods in rats
Deniz Özkan Vardar
09.00-09.45Plenary Lecture
Chair: Gülden Omurtag
Safety Evaluation of Food Additives
Yalçın Duydu
09.45-10.00Coffee Break
10.00-12.30Application of Comet Assay in Human Biomonitoring
Chairs: Mirta Milic, Joao Paolo Texeira
10.00-10.30The comet assay in human biomonitoring: results from the COST Action hCOMET
Andrew Collins
10.30-11.00Suitability of salivary leucocytes to assess DNA damage and repair in human biomonitoring studies using the comet assay
Blanca Laffon
11.00-11.30Characterization of Portuguese Wildland firefighters before a Wildfire Season: Looking at the cytogenetic effects
Joao Paolo Texeira
11.30-12.00Effect of a meat-based diet on fecal water genotoxicity: a randomized clinical trial in healthy subjects
Lisa Giovannelli
12.00-12.30The damage and protective effects on DNA after single use combination of volatile anaesthetics and gamma radiation radiotherapy of 1 or 2Gy in vivo: preliminary results
Mirta Milic
13.45-15.45In Silico Toxicology
Chairs: Hande Sipahi, Kristie Sullivan
13.45-14.15Regulatory Applications of Computational Toxicology: Progress and Strategies to Ensure Wider Use
Kristie Sullivan
14.15-14.45In silico approaches to assess the potential environmental effects of diverse chemicals
Melek Türker Saçan
14.45-15.15Filling data gap for toxicological evaluation of pharmaceuticals: In Silico approach
Muhammed Hamitoğlu
15.15-15.45In silico toxicological evaluation of drug impurities aligned with ICH M7. A case study for methylprednisolone aceponate impurities
Gülçin Tuğcu
15.45-16.00Coffee Break
13.45-15.45Current Concerns about Endocrine Disrupting Chemicals
Chairs: Hande Gürer Orhan, Belma Koçel Gümüşel
13.45-14.15Causality Between Prenatal Exposure to Pharmaceuticals and Childhood Obesity
Hande Gürer Orhan
14.15-14.45Epigenetic Effects of Endocrine Disrupting Chemicals
Belma Koçer Gümüşel
14.45-15.15Zebrafish as a Model for Chemical Induced Adipogenesis and Related Metabolic Diseases
Jorke Kamstra
15.15-15.45Risk Assessment of Endocrine Disruptors
Johanna Zilliacus
15.45-16.00Coffee Break
16.00-18.00Organ-specific Toxic Pathways: recent progress in drug-induced adversities
Chairs: Hilmi Orhan, Mathieu Vinken
16.00-16.30Paracetamol-induced kidney damage occurs by different mechanism from hepatotoxicity
Hilmi Orhan
16.30-17.00Adverse outcome pathways for in vitro prediction of liver toxicity
Mathieu Vinken
17.00-17.30The role of mitochondria in cell death and regeneration during acetaminophen hepatotoxicity
Anup Ramachandran
17.30-18.00Increasing complexity of in vitro models for drug-induced nephrotoxicity enhances their predictive value
Silvia Mihaila
20:00Gala Dinner
16.00-18.00Conceptual models in immunotoxicology: alternative approaches and computational strategies
Chairs: Özlem Atlı Eklioğlu, Marco Racchi
16.00-16.30Key characteristics of immunotoxicants: the way forward?
Dori E. Germolec
16.30-17.00In vitro tests addressing immunotoxicity with a focus on immunosuppression
Emanuela Corsini
17.00-17.30Integrated testing strategy for immunotoxicity: the agrochemical example
Marco Corvaro
17.30-18.00The Universal Immune System Simulator: an in silico model to predict the risk associated with exposure to immunotoxicants
Francesco Pappalardo (Online)
20:00Gala Dinner
13.45-15.55Oral Presentations 2
Chairs: Sinem Ilgın, Sibel Özden
13.45-13.55Role of AhR/CYP1A1 signaling in the interaction between benzo[a]pyrene and chlorpyrifos
Burcu Ünlü Endirlik
13:55-14:05Determination of exposure to organophosphate flame retardants in preschool children: a human biomonitoring study in three Turkish provinces
Hadi Attaran
14:05-14:15Cell response to N-alkyl quaternary quinuclidine oxime treatment
Suzana Žunec
14:15-14:25 Biomonitoring of Glyphosate-Based Herbicide Among Farmers in Northern Cyprus: A Pilot Study
Kumsal Kocadal
14:25-14:35The nematode Caenorhabditis elegans in Toxicity Testing: A pioneering study on the utility of this model organism
Fehmi Burak Alkas
14:35-14:45Investigation of the presence of volatile organic pollutants (VOCs) in tap water in Ankara provincial districts
Onur Kenan Ulutaş
14:45-15:05Redox status changes in rat plasma induced by phthalate and bisphenol A mixture after subacute exposure
Katarina Baralić
15:05-15:15Determination of aflatoxin m1 levels in milk samples consumed in the Turkish Republic of Northern Cyprus
Cengiz Bereket
15:15-15:25Evaluation of the apoptotic and antioxidant effects of pitavastatin in cervical cancer cell line
Aysun Ökçesiz
15:25-15:35Assessment of organophosphate and pyrethroid pesticides exposure in preschool children in Türkiye
Ayca Aktas Sukuroglu
15:35-15:45Antioxidant and protective effects of Artemisia campestris essential oil against chlorpyrifos-induced kidney and liver injuries in rats
Mongi Saoudi
15:45-15:55Microplastic Pollution in Plant Ecosystems
Hakan Özden
15:55-16:10Coffee Break
16.10-18.30Oral Presentations 3
Chairs: Emre Durmaz, Sevtap Aydın
16:10-16:20Effects of COVID-19 disease on DNA damage, oxidative stress and immune responses
Merve Hazar
16:20-16:30Apoptotic, genotoxic and immunotoxic evaluation of bisphenol derivatives exposure in HepG2 cells
Aylin Balcı Ozyurt
16:30-16:40Determination of in vitro genotoxic effects of pine resin and Aronia melonacarpa on prostate and breast cancer cell lines by using comet assay technique
Ayfer Beceren
16:40-16:50Investigation of the cytotoxic and genotoxic effects of royal jelly on healthy and cancer lung cell lines
Gökçe Taner
16:50-17:00Investigation of the Effects of Zearalenone in the Genes Related to Energy Metabolism In Vitro: Relation with the Epigenetic Alterations.
Ecem Fatma Karaman
17:00-17:10Promising novel bioinspired materials for theragnostic applications: Is the synthesis of non-cytotoxic and non-genotoxic dipeptide structures possible?
Merve Bacanlı
17:10-17:20The impact of DNA methylation on the expression of CYP3A4 gene
Seher Karslı
17:20-17:30Investigation of the Protective Effect of Walnut Oil in an in vitro Alzheimer’s Disease Model
Göksun Demirel
17:30-17:40Effect of melphalan and epigallocatechin gallate combinations on cytotoxicity in neuroblastoma cell line
Cagatay Oltulu
17:40-17:50 Investigation of the apoptotic properties of combined use of lonidamine and doxorubicin on ln229 human glioblastoma cell line
Ayşenur Bilgehan
17:50-18:00Cytotoxic effect of abemaciclib in HepG2/THP-1 co-culture model
Tugce Boran
18:00-18:10In vitro evaluation of copper ferro (II) oxide nanoparticles induced neurotoxicity
Mahmoud Abudayyak
18:10-18:20Comparative toxicity responses of THS derived from conventional cigarette and heated-tobacco products in human bronchial epithelial cells
Rengin Reis
18:20-18:30Human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) model as an assessment tool for cardiotoxicity
Zehra Şeker
20:00Gala Dinner
09.00-09.45Plenary Lecture
Chair: Emanuela Corsini
Mutidrug Resistance Protein-4 (Mrp4): A New Member in the Constellation of Factors Contributing to Non-alcoholic Liver Disease and Metabolic Syndrome
José E. Manautou
09.45-10.00Coffee Break
10.00-12.00The safety of Nanomaterials
Chairs: Heidi Foth, Murat Özmen
10.15-10.45Possible interactions and risks between nanoparticles and chemical pollutants in aquatic environments
Murat Özmen
10.45-11.15Effect of BaSO4 nanoparticles on human lung cells under different culture conditions
Heidi Foth
11.15-11.45Genotoxicity of engineered nanomaterials: New approaches to hazard and risk assessment
Maria Dusinska
12.00Closing Remarks
10.00-12.00Lipids in health and diseases
Chairs: Suna Sabuncuoğlu, Petar Bulat
10.15-10.45Sterol markers of cholesterol and bile acid metabolism
Dieter Luetjohann
10.45-11.15Sphingolipid metabolism in toxicological exposures
Suna Sabuncuoglu
11.15-11.45Role of Ceramides in Insulin Resistance and Diabetic Dyslipidemia From a Biochemical Point of View
Mutay Aslan
12.00Closing Remarks (Hall A)

11th International Congress of the Turkish Society of Toxicology


Kemankeş Karamustafa Paşa Mah.
Gümüş Halka sk. No: 4 Kat: 2-3
34425 – Karaköy /Beyoğlu / Istanbul
+90 212 243 22 40
+90 532 762 75 95


Assoc. Prof. Dr. Özlem ATLI EKLİOĞLU
Anadolu University, Faculty of Pharmacy
Department of Toxicology
26210 Tepebaşı/Eskişehir/Turkey
+90 (222) 335 0580 / 3755

Tunga Tour, 2021